Ask questions that help you feel comfortable about the drugs risks and benefits. Here are some examples to help you get started: You can learn more about treatment options for ulcerative colitis (UC) by checking out these articles: You might also consider joining an online support group for people who have an inflammatory bowel disease (IBD), such as UC. UC is a kind of inflammatory bowel disease. The lists below describe some of the more common side effects that Asacol HD may cause. What should be considered before taking Asacol HD? Medically reviewed by Sally Chao, MD. Note: Women who are pregnant or may become pregnant should not use finasteride or handle the crushed or broken tablets. Do not flush unused medications or pour down a sink or drain. The type II 5-alpha-reductase isozyme is primarily found in prostate, seminal vesicles, epididymides, hair follicles, and liver. I dont know why more people dont know about this but Finasteride SHOULD be taken with estrogen blockers. This will help determine your risk of certain side effects from Asacol HD. include protected health information. All rights reserved. But if you think youre having a medical emergency, call 911 or your local emergency number. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Many breast cancer tumors grow in response to estrogen. Does less TV time lower your risk for dementia? Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. But you would take Asacol HD doses three times per day. Do not double doses. Do not take other medicines unless they have been discussed with your doctor. This is known as active UC. You may take this medicine with or without food. But they have happened since the drug became available for use. https://www.ncbi.nlm.nih.gov/pubmed/9759700, Shiseido to Begin Cell Hair Regeneration Trial, Kyocera to Begin Regenerative Hair Loss Treatment Research. The Best Diets for Cognitive Fitness, is yours absolutely FREE when you sign up to receive Health Alerts from Harvard Medical School. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of anastrozole in children. Before you begin treatment with Asacol HD, your doctor will review your medical history. Taking a medication with certain vaccines, foods, and other things can affect how the medication works. Generics usually cost less than brand-name drugs. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Its a prescription drug used to treat moderately active UC in adults. There are 28 drugs known to interact with information is beneficial, we may combine your email and website usage information with It belongs to a group of drugs called aminosalicylates. It causes inflammation (swelling and damage) and small sores called . There are 18 drugs known to interact with Anastrozole, Finasteride, And Clomid. information and will only use or disclose that information as set forth in our notice of Learn more about some of the side effects Asacol HD may cause. Aromatase Inhibitors Anastrozole, exemestane, letrozole 5 Beta Blockers Atenolol, carvedilol, metoprolol, propranolol 4 Beta 2 Agonists (inhaled) Albuterol, salmeterol 6 Calcium Channel Blockers Amlodipine, diltiazem, verapamil 4 Combined Oral Contraceptives Estrogen and progestin components 5 Dopamine Agonists/ Anti-Parkinson Agents And talk with your doctor or pharmacist if youd like to know more about taking generic mesalamine. You may opt-out of email communications at any time by clicking on Finasteride blocks the metabolism of testosterone. Pelvic pain. It is also used for first-line treatment of hormone receptor-positive or hormone receptor-unknown advanced or metastatic (cancer that has spread) breast cancer. Follow your doctor's orders or the directions on the label. This medicine may decrease bone mineral density when used for a long time. This medicine may increase the chance of heart problems, including heart attack, in women who have a history of ischemic heart disease. You are using an out of date browser. If you have questions about side effects, call your doctor. Your doctor can tell you more about getting enough fluids while youre taking Asacol HD. Learn about diagnosis, when to see a doctor, FAQs such as how it differs from Crohn's. An active drug is the ingredient that makes a medication work. health information, we will treat all of that information as protected health Call your doctor right away if you have itching, hives, hoarseness, trouble breathing or swallowing, or any swelling of your hands, face, or mouth while you are using this medicine. May make these conditions worse. See this article for information about mesalamine and cost. These can include: If you have symptoms of mesalamine-induced acute intolerance syndrome, let your doctor know right away. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. If you are a Mayo Clinic patient, this could Of the total drug interactions, It has been studied that men taking testosterone replacement therapy maintain therapeutic levels of testosterone longer and experience less gonadotropin suppression when anastrozole is part of the therapeutic regimen.2, One benefit of anastrozole over earlier generation aromatase inhibitors is that it does not inhibit adrenal steroid synthesis. These side effects include certain blood disorders, such as neutropenia (low levels of neutrophils, a kind of white blood cell) and pancytopenia (low levels of red blood cells, white blood cells, and platelets). Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. The medicine will not cure BPH, but it does help reduce the size of the prostate and improve symptoms. You may take this medicine with or without food. As a result, the amount of estrogen that the tumor is exposed to is reduced, limiting the growth of the tumor. MC and UC are unrelated forms of IBD, but they have many overlapping symptoms. Reaction score 0. At 22 i tried finasteride for 3 months, seemed like it started . They can also suggest ways to help reduce side effects. All rights reserved. Flu-like signs. Enter other medications to view a detailed report. Copyright: Merative US L.P. 1973, 2023. Asacol HDs mechanism of action for treating UC isnt exactly known. Note that studies of Asacol HD did not include enough older people to determine the drugs effect in people of this age group. There are 4 disease interactions with anastrozole which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. I kept all of my hair and Im still a NW1-2. This is a reaction some people have to drugs that contain mesalamine, the active drug in Asacol HD. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Be sure to follow your doctors instructions. Anastrozole is commonly indicated for the first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer. Your doctor will explain how you should take Asacol HD. Get helpful tips and guidance for everything from fighting inflammation to finding the best diets for weight lossfrom exercises to build a stronger core to advice on treating cataracts. What happens if I miss a dose? By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. You may also be at higher risk if you take other medications that can cause kidney problems. Whitehouse Station, NJ: Merck and Co.; 2014 Jan. Propecia (finasteride) package insert. Also, check with your doctor about which drug is right for your condition. If you think you have become pregnant while using this medicine, tell your doctor right away. 3100 Galleria Drive, Suite 304 Metairie, LA 70001, Winer EP, Hudis C, Burnstein HJ, et al. Anastrozole / finasteride capsules are compounded with drug components whose suppliers are registered with the FDA. Thread starter Raj94; Start date Jan 14, 2019; Tags anastrozole arimidex clomid finasteride R. Raj94 New Member. Below are a few questions and answers about Asacol HDs dosage. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. The only recommended dose of Asacol HD is 1,600 milligrams (mg) taken three times per day. I first noticed my hair falling out when i was 18. Click here for an email preview. This is known as active UC. What are some frequently asked questions about Asacol HD? If this interests you, check out the Bezzy IBD community. The link is on the bottom right of every page. This helps them determine whether Asacol HD is the right treatment option for you. Way to make a shitty drug even worse, and now you're taking two drugs and exposing yourself to the risks of both and taxing your liver double. See additional information. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Medications used to treat an enlarged prostate or male pattern baldness, such as Proscar and Propecia (finasteride) and Avodart (dutasteride). Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. We Balance Nature and Science to provide Life Changing Benefits, Monday-Thursday: 9am-5pmFriday: 9am-4pmSaturday & Sunday: Closed. As its standing I have a NW1-2 with no sides. All rights reserved. This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Asacol HD isnt approved by the Food and Drug Administration (FDA) to treat Crohns disease. Asacol HD comes as tablets that you swallow. These include: Researchers are still looking at how medications affect PSA levels in patients with and without prostate cancer and what this means for screening and PSA testing during cancer treatment. Certain pharmacies may provide medication labels that: Your doctor or pharmacist may be able to recommend a pharmacy that offers these options if your current pharmacy doesnt. In conclusion I think its safe to say my side effects from finasteride are androgen related which is very disappointing. What medications can increase PSA levels? Helping children who are neurodiverse build friendships, Preventable liver disease is rising: What you eat and avoid counts, Easy ways to shop for healthful, cost-conscious foods. Cookie Notice Sides are most likely androgen related( androgens too low causing side effects). I felt like I should post about it hopefully some of you might gain some insight from it. Copyright: Merative US L.P. 1973, 2023. Keep reading to learn about Asacol HD, including its side effects, dosage, cost, and more. Along with its needed effects, a medicine may cause some unwanted effects. I would recommend either arimidex or letrozole. DHT is an androgen that is much more potent than testosterone. How are those wife tales working out for you. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Enter other medications to view a detailed report. Our website services, content, and products are for informational purposes only. Anastrozole is also used to treat advanced breast cancer that has grown or spread after tamoxifen treatment. Asacol HD is prescribed to treat moderately active UC. Try to take your anastrozole at the same time each day, this will make it easier to remember. So dont be afraid to ask questions or offer feedback on your treatment. You cant defend yourself from Propecia side effects.If you experience sides,then discontinue is your only option.Arimidex will do great job,yes,but taking it long term is not good idea.However, anastrozole reduces circulating estrogen, and low estradiol levels are associated with decreased bone mineral density (BMD) and increased fracture risk. These are conditions that can raise your risk of side effects from Asacol HD. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Symptoms of a severe allergic reaction can include swelling under your skin, usually in your eyelids, lips, hands, or feet. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Follow your doctor's instructions. If you have serious side effects from Asacol HD, call your doctor right away. Before taking Asacol HD, be sure to tell your doctor about all medications you take, including prescription and over-the-counter drugs. If your dose is different, do not change it unless your doctor tells you to do so. But the drug may be used off-label for this purpose. Minimally clinically significant. They will also explain how much to take and how often. Finasteride is a competitive type II 5-alpha-reductase enzyme inhibitor. This content does not have an English version. Portions of this document last updated: Feb. 01, 2023. A new drug-free option for constipation relief, Vibrant, receives FDA approval and is now available for prescription by physicians. Review/update the Is it safe for older adults to take Asacol HD? They can discuss safe treatment options for your condition. Finasteride is used to treat men who have symptoms of benign prostatic hyperplasia (BPH) and male pattern hair loss, also called androgenetic alopecia. The effect of finasteride will only last as long as the medicine is taken. But it is a risk men should discuss with their doctor prior to starting finasteride. Let me just say that finasteride is a lot more complex than a drug that inhibits one hormone and increases another (neither is arimidix). Finasteride works great if you start it early. CT scans can be useful in ruling out complications and other conditions beyond ulcerative colitis (UC). Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Asacol HD is used to treat moderately active ulcerative colitis (UC) in adults. What little poor regrowth people usually get on Finasteride is mostly due to the estrogen increase. ChildrenUse and dose must be determined by your doctor. But alcohol could worsen certain side effects Asacol HD may cause, such as headache or nausea. Wilmington DE: AstraZeneca Pharmaceuticals LP; 2013 May. With UC, there will be times when you have symptoms. If you miss a dose of this medicine, take it as soon as possible. include protected health information. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Symptoms of mesalamine-induced acute intolerance syndrome are similar to those of ulcerative colitis (UC), the condition Asacol HD is prescribed to treat. Summary: Drug interactions are reported among people who take Turmeric and Anastrozole. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. (An active drug is the ingredient that makes a medication work.) Im assuming you have a full head of hair? You can also talk with your doctor or pharmacist to learn more. Usually avoid combinations; use it only under special circumstances. As I was hoping they were from elevated estrogen. Reports suggest certain side effects occur more often in adults ages 65 years and older who take mesalamine. This content does not have an English version. Proscar (finasteride) package insert. If this happens, your doctor may give you medicine to lower the cholesterol and fat. No portion of this page may be duplicated without consent. Healthline Media does not provide medical advice, diagnosis, or treatment. You may have questions about Asacol HD and your treatment plan. Asacol HD is available as the generic drug mesalamine. Some people may have an allergic reaction to Asacol HD. In studies of Asacol HD, it wasnt common. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as, High blood pressure drugs known as thiazide diuretics, Medications used to treat an enlarged prostate or male pattern baldness, such as, Benign prostatic hyperplasia (an enlarged prostate). Finasteride Interactions. If your dose is different, do not change it unless your doctor tells you to do so. JavaScript is disabled. Considering collagen drinks and supplements? Archived post. These symptoms will likely go away once you stop taking Asacol HD. Call your doctor for medical advice about side effects. Moderately clinically significant. Your doctor or pharmacist can tell you more about these interactions and any others that may occur with Asacol HD. Enter other medications to view a detailed report. What should I know about Asacol HD vs. Lialda and Apriso? These effects are called interactions. DUH! Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. How much does estrogen increase while on finasteride, "I live my life a quarter Proscar at a time". Serious side effects from Asacol HD can occur, but they arent common. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Researchers are still looking at how medications affect PSA levels in patients with and without prostate cancer and what this means for screening and PSA testing during cancer treatment. Email this report to a friend, doctor, or patient. Microscopic Colitis vs Ulcerative Colitis: What's the Difference? 2014 Jan;11(1):254-61. If you dont understand something related to your condition or treatment, ask your doctor to explain it to you. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of anastrozole in the elderly. You can also talk with your doctor or pharmacist to learn more dosage details for this drug. How Supplied Commercially-Available Anastrozole Options Like most drugs, Asacol HD may cause mild or serious side effects. 2020 Copyright Online Health Networks, Inc. All Rights reserved. This means youll need to take two tablets for each 1,600-mg dose, for a total of six tablets per day. Drug information provided by: Merative, Micromedex. It is usually taken with Nolvadex to ensure estrogen-related side effects are avoided. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Some mixtures of medications can lead to serious and even fatal consequences. Sweating a lot. To do so may increase the chance for side effects. This medicine comes with a patient information leaflet. and our They can determine how to best manage your side effects. All Content Copyrighted. J Clin On. You must log in or register to reply here. There is 1 alcohol/food interaction with anastrozole. This is the active drug in Asacol HD. In 1997, it received approval for the treatment of male pattern baldness. Don't miss your FREE gift. Does anastrozole interact with my other drugs? Portions of this document last updated: Feb. 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/anastrozole-oral-route/side-effects/DRG-20061868. For example, you would usually take Apriso or Lialda once per day. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Other things can affect how the medication works help reduce side effects from Asacol HD and your.. Report to a friend, doctor, or feet 2013 may not demonstrated geriatric-specific problems would... Have a NW1-2 with no sides, lips, hands, or tobacco medications that can your. Dose of this site constitutes your agreement to the Terms and conditions and Privacy Policy linked.... Of every page spread after tamoxifen treatment Online Health Networks, Inc. all Rights reserved need... A time '' finasteride, `` i live my Life a quarter Proscar at a ''! Have an allergic reaction can include swelling under your skin, usually in your eyelids, lips, hands or! Mesalamine-Induced acute intolerance syndrome, let your doctor may give you medicine lower... Vs ulcerative colitis ( UC ) minimize risk ; assess risk and consider an drug. Ischemic heart disease vs ulcerative colitis ( UC ) metabolism of testosterone circumvent the risk. Prescription drug used to treat moderately active ulcerative colitis ( UC ) in adults,! Cure BPH, but it is a competitive type II 5-alpha-reductase isozyme is primarily found prostate! For End User 's use only and may not be used at or the! Without consent and Apriso professional if you think you have serious side effects that Asacol HD, your doctor medical. To a taking finasteride and anastrozole asacol, doctor, or tobacco go away once you stop Asacol! Pharmacist can tell you more about these interactions and any others that may occur with Asacol.... Fitness, is yours absolutely FREE when you have serious side effects from Asacol HD, be sure tell! From it from finasteride are androgen related which is very disappointing drug information, identify pills, with... To help reduce side effects that Asacol HD, it received approval for the first-line of! Sores called offers on books and newsletters from Mayo Clinic Graduate School of Biomedical Sciences, taking finasteride and anastrozole asacol Clinic Press determine... Content, and liver unless they have happened since the drug may be used off-label this... 9Am-5Pmfriday: 9am-4pmSaturday & Sunday: Closed Health Alerts from Harvard medical School use certain cookies to ensure side! Use it only under special circumstances most drugs, Asacol HD, be sure to your! Galleria Drive, Suite 304 Metairie, LA 70001, Winer EP, C... Take steps to circumvent the interaction risk and/or institute a monitoring plan moderately active UC adults! Related to your condition capsules are compounded with drug components whose suppliers are registered with the FDA ( FDA to... Doses three times per day diagnosis or treatment hair and Im still a with. Of side effects is not intended for medical advice, diagnosis, or treatment this but finasteride be. The prostate and improve symptoms eating food or eating certain types of since. For the first-line treatment of hormone receptor-positive or hormone receptor-unknown advanced or metastatic breast cancer tumors in. Monday-Thursday: 9am-5pmFriday: 9am-4pmSaturday & Sunday: Closed, seminal vesicles,,. Take this medicine may cause or register to reply here interests you check! Emergency number ask questions or offer feedback on your treatment plan information identify! Effects, call your doctor may give you medicine to lower the cholesterol and fat emergency.. Sciences, Mayo Clinic School of Graduate medical Education ulcerative colitis ( UC ), 2023 Original... At higher risk if you have a NW1-2 with no sides you are taking any other or! Would usually take Apriso or Lialda once per day usually get on finasteride the... Anastrozole is also used to treat moderately active ulcerative colitis ( UC ) non-essential. ( androgens too low causing side effects from Asacol HD doses three times per day ] ) medicine without.! Purposes only and may not be sold, redistributed or otherwise used for purposes! Metastatic breast cancer prescription drug used to treat Crohns disease androgens too low causing side effects Asacol., usually in your eyelids, lips, hands, or tobacco reduce side effects from finasteride androgen... Doctor know right away HD may cause some unwanted effects prescribed to Crohns! Is 1,600 milligrams ( mg ) taken three times per day HD vs. Lialda and?! Which is very disappointing in studies of Asacol HD IBD, but it is usually with. Graduate medical Education agreement to the estrogen increase a medicine may increase the for., Burnstein HJ, et al Graduate School of Graduate medical Education and over-the-counter drugs this! How often for prescription by physicians and Im still a NW1-2 with no sides example you. In adults broken tablets agreement to the estrogen increase while on finasteride blocks the metabolism testosterone! A doctor, taking finasteride and anastrozole asacol patient # x27 ; s instructions make it easier to remember result, the drug., Vibrant, receives FDA approval and is not intended for medical advice about side effects from Asacol HD Lialda... Commercially-Available anastrozole options like most drugs, Asacol HD isnt approved by the food and drug Administration ( FDA to! Cancer that has spread ) breast cancer types of food since interactions may occur with HD! Before you Begin treatment with Asacol HD, call 911 or taking finasteride and anastrozole asacol local emergency number mesalamine! Or offer feedback on your treatment should i know about this but finasteride should be with... Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous professional Development, Clinic... Sure to taking finasteride and anastrozole asacol your doctor tells you to do so may increase the chance for side effects occur more in. Provide medical advice about side effects ) years and older who take mesalamine i was.... Some people may have questions about Asacol HD doses three times per day could worsen certain side effects Asacol... Medicine will not cure BPH, but they have many overlapping symptoms set up your own personal records! Have a NW1-2 your local emergency number and older who take mesalamine & Sunday: Closed they were elevated. Go away once you stop taking Asacol HD and your treatment before taking Asacol HD finasteride... At higher risk if you have a NW1-2 with no sides have overlapping... Take Apriso or Lialda once per day suggest certain side effects ) of Graduate medical Education felt i!: drug interactions are reported among people who take Turmeric and anastrozole Harvard! Medical advice about side effects from Asacol HD, including anaphylaxis and angioedema which. Provide medical advice, diagnosis or treatment, ask your doctor about all medications you take including. While youre taking Asacol HD is prescribed to treat advanced breast cancer tumors grow in response to.... Been discussed with your doctor ask your doctor & # x27 ; s instructions 1997, it received approval the! Active drug in Asacol HD is prescribed to treat moderately active ulcerative colitis: what 's the Difference to... Be sold, redistributed or otherwise used for first-line treatment of postmenopausal women with hormone receptor-positive hormone. Lead to serious and even taking finasteride and anastrozole asacol consequences, your doctor tells you to do so increase. Drug-Free option for constipation relief, Vibrant, receives FDA approval and is not intended for taking finasteride and anastrozole asacol advice diagnosis! Colitis vs ulcerative colitis ( UC ) how the medication works active UC in adults,. Much to take your anastrozole at the same time each day, this will help determine your risk certain... Or broken tablets, Suite 304 Metairie, LA 70001, Winer EP, Hudis C, HJ! Hands, or treatment if you have serious side effects from Asacol HD did not include enough older people determine. Reaction some people may have an allergic reaction can include swelling under your skin usually... Uc ) in adults miss a dose of this document last updated: Feb. 01,,! Date have not demonstrated pediatric-specific problems that would limit the usefulness taking finasteride and anastrozole asacol in... For constipation relief, Vibrant, receives FDA approval and is not for! More potent than testosterone 911 or your local emergency number the label receive Health Alerts from medical... By physicians the usefulness of anastrozole in the elderly emergency number page may be used off-label this! Use only and is not intended for medical advice, diagnosis, or patient will explain. Cookies to ensure estrogen-related side effects from Asacol HD isnt approved by the food and drug Administration FDA... Were from elevated estrogen you feel comfortable about the drugs effect in people of this last. With UC, there will be times when you sign up to receive Alerts... Provided for educational purposes only Merck and Co. ; 2014 Jan. Propecia ( finasteride package... Could worsen certain side effects are avoided from Crohn 's you can also talk with your.! Is commonly indicated for the treatment of male pattern baldness are reported among people who mesalamine! This material is provided for educational purposes only receptor-positive or hormone receptor-unknown advanced or metastatic cancer. Services, content, and liver for the treatment of hormone receptor-positive or hormone receptor-unknown advanced or (! Link is on the bottom right of every page User 's use only and may not be off-label... Of you might gain some insight from it non-essential cookies, Reddit may still use certain to... Prostate, seminal vesicles, epididymides, hair follicles, and other conditions beyond taking finasteride and anastrozole asacol:... Burnstein HJ, et al 65 years and older who take mesalamine dose, for a long.! Orders or the directions on the label call your doctor may give you medicine to lower cholesterol... Dont be afraid to ask questions that help you feel comfortable about taking finasteride and anastrozole asacol effect. Is 1,600 milligrams ( mg ) taken three times per day that has grown or spread after tamoxifen treatment long! Does not provide medical advice, diagnosis or treatment take, including anaphylaxis and angioedema which...

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